In this continuation of the roundtable series on acute myeloid leukemia (AML), experts delve deeper into the evolving treatment landscape, focusing on the transformative role of targeted therapies. Led by Amer M. Zeidan, MBBS, of Yale School of Medicine, the discussion highlights emerging novel agents and their potential to refine personalized treatment strategies. The panel examines the mechanisms, clinical applications, and challenges of incorporating these innovations into AML care.