The data herein supports the novel role of mutant CCR4 in enhancing T-cell lymphomagenesis and T-helper differentiation. These highly encouraging data support further evaluation of epcoritamab. NX-5948 showed tolerable safety and promising responses in patients with relapsed or refractory CLL or non-Hodgkin lymphoma. Acalabrutinib and zanubrutinib demonstrated better safety and efficacy outcomes when compared with ibrutinib in CLL/SLL.