Primary myelofibrosis developed secondary neoplasms earlier and at higher rates versus other myeloproliferative neoplasms. Essential thrombocythemia with CALR mutations had a higher risk of progression to myelofibrosis compared with JAK2 mutations. A deep learning-based pathomics approach had potential in estimating bone marrow cellularity in patients with MPNs. MPNs were not the primary cause of strokes in veterans, though researchers found they were strongly associated. Patients with polycythemia vera developed secondary malignancies at a higher rate versus other myeloproliferative neoplasms.