SITC2023
CLN-978 was designed for high-affinity binding to CD19 and to enable the killing of low-CD19 expressing blasts.
The strategy is “potentially translatable to all T-cell derived hematological malignancies," according to researchers.
RNA sequencing showed decreased gene expression levels of the NF-κB target genes IL1β and IER3 after emavusertib treatment.
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