Acute Lymphoblastic Leukemia
The latest news, research, and perspectives in acute lymphoblastic leukemia (ALL). The most common type of leukemia in children, ALL develops when bone marrow produces a large number of immature lymphoblasts that grow quickly and replace normal cells in the bone marrow.
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The US FDA approved blinatumomab for the treatment of CD19-positive, Philadelphia chromosome-negative B-cell precursor ALL.
Investigators identified pre- and postinfusion factors linked to severe hematotoxicity, as defined by EHA/EBMT criteria.
In this executive editor's message, Elias Jabbour, MD, writes about redefining leukemias as curable or less curable.
A phase II study presented at ASPHO 2024 evaluated revumenib in KMT2A-rearranged ALL and AML.
The researchers found that CALM-AF10 leukemia cells grow slower after the SIX1 knockdown.
Efficacy was based on the MRD-negative CR rate at the end of induction.
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Elias Jabbour, MD, joined "The HemOnc Pulse" to discuss the function of MRD in treating ALL.
The efficacy of inotuzumab ozogamicin was assessed in a multicenter, single-arm, open-label study in 53 pediatric patients.
UM171 promotes degradation of the CoREST1 complex and reduces levels of chromatin-bound MYC.
Most patients in the lower-dose group achieved complete remission or complete remission with partial hematologic recovery.
The percentage of KMT2A-altered cells decreased from 59.2% to 8.1% after treatment with JNJ-75276617.
53.8% of patients treated with blinatumomab achieved MRD negativity within a median of 3.1 months, as detected with clonoSEQ.
Dr. Patel and the hosts discuss the TRANSFORM-1 study, MANIFEST-2, AUGMENT-101, and more.
The past two decades have witnessed a rapid change in the treatment of acute lymphoblastic leukemia.
The approval is based on the clinical results from a single-arm, multicenter, pivotal study in China.
The study determined the maximum tolerated dose of asciminib with dasatinib and prednisone.
93% of patients became measurable residual disease (MRD) negative after the first cycle of blinatumomab.
Adding blinatumomab to consolidation chemotherapy represents a new standard of care in newly diagnosed B-lineage ALL.
After a follow-up of 24 months, the two-year relapse free survival was 54% and the two-year overall survival rate was 60%.
The effect of elevated BMI was more pronounced in older adolescent and young adults (AYAs) compared to younger AYAs.
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Editorial Board
Sagar Lonial, MD, FACPEditor-in-Chief | Chief Medical Officer of Winship Cancer Institute at Emory University School of Medicine
Guillermo Garcia-Manero, MDAssociate Editor | Chief, Section of Myelodysplastic Syndromes, The University of Texas MD Anderson Cancer Center
Elias Jabbour, MDExecutive Editor | DB Lane Cancer Research Fund Distinguished Professor in Leukemia Research, MD Anderson Cancer Center
Kami Maddocks, MDAssociate Editor | Professor of Clinical Internal Medicine in the Division of Hematology at The Ohio State University
Thomas Martin, MDAssociate Editor | Clinical Research Director, UCSF Helen Diller Family Comprehensive Cancer Center
Jerald Radich, MDAssociate Editor | Professor in the Clinical Research Division and Kurt Enslein Endowed Chair at Fred Hutch
Laurie Sehn, MD, MPHAssociate Editor | Clinical Professor of Medical Oncology, British Columbia Cancer Centre for Lymphoid Cancer
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