Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia
The latest news, research, and perspectives in acute lymphoblastic leukemia (ALL). The most common type of leukemia in children, ALL develops when bone marrow produces a large number of immature lymphoblasts that grow quickly and replace normal cells in the bone marrow.
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Leah SherwoodMeeting News | June 2, 2023
Dr. Hill and colleagues presented their research on the CAR-T manufacturing approach during the 2023 ASCO meeting.
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Cecilia BrownAcute Lymphoblastic Leukemia | May 26, 2023
Most patients (83%) responded to the treatment, with 63% having a complete response.
Cecilia BrownAcute Lymphoblastic Leukemia | May 25, 2023
The study evaluated an NGS assay and its correlation with RT-PCR assay results for BCR::ABL in patients with Ph+ ALL.
Cecilia BrownAcute Lymphoblastic Leukemia | May 23, 2023
The two-year PFS rate was 58.2%, while the five-year PFS rate was 44% at a median follow-up of 92.8 months.
Anastasia Tikhonova, PhDAcute Lymphoblastic Leukemia | May 9, 2023
Anastasia Tikhonova, PhD, was named a 2023 NextGen Star by the AACR.
Cecilia BrownAcute Lymphoblastic Leukemia | May 1, 2023
The 18-month overall survival rate was 75%, while the event-free survival rate was 53.1%.
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Leah SherwoodVideo Insights | April 20, 2023
Anastasia Tikhonova, PhD, talks about her research on the immune microenvironment in T-cell ALL.
Cecilia BrownAcute Lymphoblastic Leukemia | April 12, 2023
AUTO1 is a “fast off-rate CD19 binding domain CAR designed to reduce immune toxicity and improve engraftment."
Cecilia BrownAcute Lymphoblastic Leukemia | April 10, 2023
The study’s authors did not report any new or unexpected long-term adverse events.
Cecilia BrownAcute Lymphoblastic Leukemia | April 10, 2023
The researchers studied real-world outcomes of pediatric patients with B-cell ALL who recieved tisagenlecleucel.
Cecilia BrownAcute Lymphoblastic Leukemia | February 24, 2023
No relapses occurred in patients who achieved early MRD negativity per the next-generation sequencing MRD assay.
Cecilia BrownMeeting News | February 21, 2023
Brexucabtagene autoleucel led to “high rates of durable response” in adults with relapsed/refractory B-cell ALL.
Leah SherwoodAcute Lymphoblastic Leukemia | February 15, 2023
Ponatinib was more effective than imatinib when given with reduced-intensity chemotherapy in newly diagnosed Ph+ ALL.
Cecilia BrownAcute Lymphoblastic Leukemia | February 9, 2023
All patients had a complete response after the first infusion, while 67% had a complete response after the second infusion.
Cecilia BrownAcute Lymphoblastic Leukemia | February 3, 2023
The efficacy of CNS prophylaxis with intrathecal chemotherapy in Ph+ ALL depends upon how many times it is given.
Cecilia BrownAcute Lymphoblastic Leukemia | February 1, 2023
Ponatinib plus hyper-CVAD led to "excellent" outcomes in patients with newly diagnosed Ph+ ALL.
Cecilia BrownAcute Lymphoblastic Leukemia | January 31, 2023
A chemotherapy-free regimen with ponatinib and blinatumomab led to high complete molecular response rates in Ph+ ALL.
Cecilia BrownAcute Lymphoblastic Leukemia | January 10, 2023
A chemotherapy-free regimen led to high rates of complete remission and MRD negativity in patients with Ph+ ALL.
Cecilia BrownAcute Lymphoblastic Leukemia | January 10, 2023
Inotuzumab ozogamicin plus hyper-CVAD with sequential blinatumomab is safe and effective for Ph-negative B-cell ALL.
Cecilia BrownAcute Lymphoblastic Leukemia | January 10, 2023
Adding blinatumomab to consolidation chemotherapy led to improved survival in MRD-negative patients with B-lineage ALL.
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