Myelofibrosis
The latest news, research, and perspectives in myelofibrosis (MF). A primary subtype of myeloproliferative neoplasms (MPNs), this rare blood cancer scars the bone marrow so that it cannot properly produce blood cells.
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The phase III PERSIST-2 study compared symptom results from pacritinib with those of best available therapy and ruxolitinib.
Patients' genomic profiles and baseline laboratory values have implications for their treatment outcomes with these agents.
The International Prognostic Scoring System, Dynamic International Prognostic Scoring System, and other models were applied.
A retrospective study found momelotinib plus pacritinib led to reduced need for red blood cell transfusion in patients.
A real-world retrospective study evaluated transfusion dependent or nondependent patients at ruxolitinib initiation.
Management of asymptomatic, clinically stable disease is not necessarily improved by implementing routine hemostasis tests.
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Investigational agent DISC-0974 produced anemia response independent of patient transfusion dependency or JAK inhibitor use.
A study observed that addition of pelabresib to ruxolitinib led to bone marrow microenvironment improvement.
An expert on myelofibrosis comments on promising results from current trials and on the need for useful clinical biomarkers.
History of thrombotic events, hematocrit ≤0.45 L/L, and JAK2 p.V617F were identified as risk factors for progression.
LOXL2 upregulation is associated with key inflammatory signaling pathways in primary myelofibrosis.
Treatment with selinexor reduced hepcidin and pro-inflammatory cytokines in patients with myelofibrosis.
The rates of baseline comorbidities and constitutional symptoms were higher in patients with anemia versus those without.
New or worsening anemia following initiation of ruxolitinib does not appear to diminish clinical benefit.
Hemoglobin improvement at week 24 after transfusion is associated with improved HRQOL in myelofibrosis and anemia.
Prospective analysis suggest that 4.3% of patients with ET progressed to myelofibrosis over five years of follow up.
Patients with MF or ET with CALR or JAK2 mutations carried similar symptom burdens according to prospective data.
The phase III MANIFEST-2 trial compared pelabresib plus ruxolitinib with placebo plus ruxolitinib in JAKi-naive patients.
The findings were from a retrospective study of patient data from the US Flatiron Health electronic health record database.
A retrospective analysis covered two phase III trials of the JAK2 inhibitor in patients with and without monocytosis.
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Editorial Board
Sagar Lonial, MD, FACPEditor-in-Chief | Chief Medical Officer of Winship Cancer Institute at Emory University School of Medicine
Guillermo Garcia-Manero, MDAssociate Editor | Chief, Section of Myelodysplastic Syndromes, The University of Texas MD Anderson Cancer Center
Elias Jabbour, MDExecutive Editor | DB Lane Cancer Research Fund Distinguished Professor in Leukemia Research, MD Anderson Cancer Center
Kami Maddocks, MDAssociate Editor | Professor of Clinical Internal Medicine in the Division of Hematology at The Ohio State University
Thomas Martin, MDAssociate Editor | Clinical Research Director, UCSF Helen Diller Family Comprehensive Cancer Center
Jerald Radich, MDAssociate Editor | Professor in the Clinical Research Division and Kurt Enslein Endowed Chair at Fred Hutch
Laurie Sehn, MD, MPHAssociate Editor | Clinical Professor of Medical Oncology, British Columbia Cancer Centre for Lymphoid Cancer
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