Prithviraj Bose, MD, of MD Anderson Cancer Center, Francesca Palandri, MD, PhD, of Università di Bologna, Andrew Kuykendall, MD, of Moffitt Cancer Center, and Lucia Masarova, MD, of MD Anderson Cancer Center discuss the current treatment landscape for myelofibrosis. These renowned experts share their perspectives on emerging therapies, clinical challenges, and advancements in managing this complex condition.