Transplantation & Cellular Therapy
Transplantation & Cellular Therapy
The latest news, research, and perspectives in transplantation and cellular therapy. Hematopoietic cell transplantation involves replacing unhealthy bone marrow with healthy stem cells in patients with hematologic disorders. In the growing field of non-transplant cellular therapies, including chimeric antigen receptor T-cell therapies, patient- or donor-derived cells are being explored for the treatment and potential cure of blood cancers.
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Andrew MorenoTransplantation & Cellular Therapy | October 24, 2024
A study has compared responses with anti-CD19 CAR-T therapy in MCL with and without active CNS involvement at infusion.
Andrew MorenoTransplantation & Cellular Therapy | October 24, 2024
An MAIC analysis of data from clinical trials identified differences in efficacy and safety between the two interventions.
Andrew MorenoTransplantation & Cellular Therapy | October 23, 2024
The authors found the complete response rate results to be promising and to warrant further clinical investigation.
Melissa BadamoTransplantation & Cellular Therapy | October 4, 2024
Bilal Abid, MD, describes how to approach sequencing pirtobrutinib after CAR-T therapy.
Melissa BadamoTransplantation & Cellular Therapy | October 24, 2024
Dr. Abid describes when he uses bispecifics versus CAR-T in his practice at the University of Texas Health Science Center.
Andrew MorenoTransplantation & Cellular Therapy | October 7, 2024
Encouraging efficacy and safety seen over 17 months in a phase II trial continued into the trial's 29-month follow-up period.
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Andrew MorenoTransplantation & Cellular Therapy | October 7, 2024
In a retrospective study bendamustine compared favorably with the cyclophosphamide plus fludarabine lymphodepletion regimen.
Andrew MorenoTransplantation & Cellular Therapy | October 7, 2024
A first ever phase I/II trial tested escalating doses in patients with relapsed or refractory disease.
Andrew MorenoTransplantation & Cellular Therapy | July 17, 2024
Axi-cel produced sustained long-term responses in patients with follicular lymphoma and marginal zone lymphoma.
Andrew MorenoTransplantation & Cellular Therapy | July 18, 2024
A phase II trial found antitumor effect across patient subgroups and independently of risk factors for disease progression.
Patrick DalyFollicular Lymphoma | October 4, 2024
Treatment with liso-cel was effective and safe in patients with relapsed or refractory follicular lymphoma in TRANSCEND FL.
Manali Kamdar, MDTransplantation & Cellular Therapy | August 23, 2024
Manali Kamdar, MD, shared results from the pivotal phase III TRANSFORM study on lisocabtagene maraleucel in LBCL.
Melissa BadamoAggressive B-Cell Lymphoma | June 3, 2024
Patients with relapsed refractory LBCL can derive clinical benefit from liso-cel NCP without compromising safety.
Melissa BadamoFollicular Lymphoma | June 3, 2024
The median progression-free survival, duration of response, and overall survival were not reached.
Leah LawrenceTransplantation & Cellular Therapy | May 22, 2024
Benefits of CAR T-cell therapy outweigh the hypothetical future risk of secondary malignancies.
Magdi Elsallab, MD, PhDTransplantation & Cellular Therapy | April 17, 2024
In approximately 12,000 reports of adverse events, the researchers found 19 cases of T-cell malignancies after CAR-T.
Melissa BadamoTransplantation & Cellular Therapy | May 21, 2024
The investigators reviewed case reports of patients 20 years old and younger who underwent therapy for BPDCN.
Sarah ValentineAcute Myeloid Leukemia | April 2, 2024
HMA plus venetoclax was found to be effective and well tolerated in patients with AML who relapsed after HSCT.
Sarah ValentineAggressive B-Cell Lymphoma | March 26, 2024
Adding ofatumumab to reduced intensity conditioning is safe and effective in high-risk B-cell non-Hodgkin lymphoma.
Douglas Tremblay, MDMyelodysplastic Syndromes | March 15, 2024
The study also explored the role of this combination in transitioning patients to HSCT.
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