Risk Factors for Patients with CK-MDS Undergoing Allogeneic HSCT

A recent study published in British Journal of Haematology aimed to identify risk factors for patients with complex karyotype myelodysplastic syndrome (CK-MDS) undergoing allogeneic hematopoietic stem cell transplantation (HSCT).

Researchers discovered that several factors were “significantly associated with [overall survival (OS)].” These include:

• Older age
• Male sex
• Poor hematopoietic cell transplant comorbidity
• Red blood cell transfusion requirement
• Platelet transfusion requirement
• Not-complete remission
• A high number of karyotype abnormalities
• Monosomal karyotype

Yoshimitsu Shimomura, MD, of the Department of Hematology at Kobe City Medical Center General Hospital in Japan, conducted the study because “only a few studies have been limited to patients with CK-MDS undergoing allogeneic HSCT.”

The multivariable analysis included 691 patients with CK-MDS who received their first allogeneic HSCT. The three-year OS of allogeneic HSCT, estimated using the Kaplan-Meier method, was determined to be 29.8% in patients with CK-MDS. Prognostic factors were identified using a Cox proportional hazards model.

Reference

Shimomura Y, Komukai S, Kitamura T, et al. The prognosis and risk factors for patients with complex karyotype myelodysplastic syndrome undergoing allogeneic haematopoietic stem cell transplantation. Br J Haematol. 2023. doi:10.1111/bjh.19139