Myelodysplastic Syndromes
The latest news, research, and perspectives in myelodysplastic syndromes (MDS). Subtypes of this heterogeneous group of disorders occur when blood-forming cells in the bone marrow become abnormal. Sometimes, MDS precedes acute myeloid leukemia.
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The COMMANDS trial evaluated frontline luspatercept in transfusion-dependent patients with lower-risk MDS and anemia.
Issues addressed include mandatory versus optional biopsy, informed consent, and safety in both adult and pediatric patients.
HMAs, either as monotherapy or in combination with venetoclax, represent the standard of care for higher-risk MDS or AML.
According to a study, patients with MDS and CMML have dismal clinical outcomes after failure of HMA therapy.
Investigational combinations for MDS appeared to be well tolerated while triplets results in high-grade toxicity.
An expert speaks on site at ASH 2024 about the health-related quality of life data from the phase 3 COMMANDS trial.
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Phase 2 study results outline benefit of adding venetoclax to intensive chemo in MDS and AML patients.
Moving forward, prospective studies must validate these findings and refine risk stratification tools like the IPSS-R in MDS.
Some patients with ZRSR2-mutated CCUS had concurrent blood cancers or disorders, and others had protective co-mutation.
A discussion on the post hoc analysis on quality of life from the COMMANDS trial.
Discussing the COMMANDS trial and sequencing luspatercept in patients with myelodysplastic syndromes.
How to address ESA failure or ineligibility in patients with MDS...
Results from a real-world analysis of post-ESA treatment outcomes in patients with lower-risk myelodysplastic syndrome.
Early signs of clinical activity have been shown in a phase I/II study of tagraxofusp/decitabine in MDS and CMML.
Mature data of three immunotherapy-based hypomethylating agent combinations were presented at ASH.
High complete response rates and low early mortality rates facilitate the majority of patients to allogeneic SCT.
An ongoing phase 1 study is evaluating the safety and efficacy of danvatirsen through two substudies.
New WHO and ICC 022 guidelines propose lowering the threshold for diagnosis of CMML.
High-risk MDS is associated with poor outcomes, making the assessment of treatment response critical.
A myelofibrosis cohort showed that tapering to achieve molecular remission helped promote OS after transplant.
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