Myelodysplastic Syndromes
Myelodysplastic Syndromes
The latest news, research, and perspectives in myelodysplastic syndromes (MDS). Subtypes of this heterogeneous group of disorders occur when blood-forming cells in the bone marrow become abnormal. Sometimes, MDS precedes acute myeloid leukemia.
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Leah SherwoodMyelodysplastic Syndromes | March 24, 2023
The EC approval of luspatercept was based on results from the phase II BEYOND study.
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Cecilia BrownMyelodysplastic Syndromes | March 6, 2023
Treatment of LR-MDS remains an unmet need and goals of therapy should extend beyond transfusion independence.
Leah SherwoodMyelodysplastic Syndromes | March 6, 2023
MDS/AML are among independent predictors of COVID-19 treatment failure.
Cecilia BrownMyelodysplastic Syndromes | March 3, 2023
Oxidized mitochondrial DNA can “prime” MDS HSPCs for inflammasome activation.
Cecilia BrownMyelodysplastic Syndromes | February 14, 2023
Low-risk MDS can have high-risk features, but current MDS prognostic scoring systems may not capture key risk variables.
Cecilia BrownMyelodysplastic Syndromes | February 14, 2023
While the fifth edition “softened” the boundary between MDS and AML, it retains the 20% blast cutoff to define AML.
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Cecilia BrownMyelodysplastic Syndromes | February 7, 2023
Exposure to thalidomide analogs is associated with TP53 mutations in patients with therapy-related myeloid neoplasms.
Leah SherwoodMyelodysplastic Syndromes | February 7, 2023
Luspatercept reduced RBC transfusion units and visits in patients with lower-risk MDS with ring sideroblasts.
Cecilia BrownMyelodysplastic Syndromes | February 5, 2023
A panel recently made a consensus proposal to revise the IWG response criteria for higher-risk MDS.
Leah SherwoodMyelodysplastic Syndromes | January 27, 2023
The U.S. FDA granted Fast Track Designation to tamibarotene, an oral selective RARα agonist, for higher-risk MDS.
Chadi Nabhan, MD, MBA, FACPThe HemOnc Pulse | January 26, 2023
Sanam Loghavi, MD, chats with The HemOnc Pulse host Chadi Nabhan, MD, MBA, FACP, about why 2022 was a major year for MDS.
Cecilia BrownAcute Myeloid Leukemia | January 26, 2023
A participant’s death led to a voluntary pause of a phase I/II trial evaluating MGTA-117 in relapsed/refractory AML and ...
Leah SherwoodMyelodysplastic Syndromes | January 19, 2023
Long-term safety data for luspatercept showed no new safety signals in lower-risk MDS.
Leah SherwoodMyelodysplastic Syndromes | January 19, 2023
Venetoclax plus azacitidine provided “clinically meaningful benefits” in R/R/ MDS post-HMA failure.
Leah SherwoodMyelodysplastic Syndromes | January 19, 2023
Researchers have developed and externally validated a clinical-molecular prognostic model for risk stratification in MDS.
Cecilia BrownMyelodysplastic Syndromes | January 6, 2023
Patients with MDS who received active therapy soon after their diagnosis had better outcomes than those who did not.
Leah SherwoodPrint | December 22, 2022
DocMatter members weigh in on the use of venetoclax in patients with higher-risk myelodysplastic syndromes.
Blood Cancers Today Staff WritersMeeting News | December 16, 2022
Survival rates for MDS/MPN overlap syndromes vary significantly by clinical entity.
Blood Cancers Today Staff WritersMeeting News | December 16, 2022
A phase III trial confirmed the efficacy of lenalidomide in transfusion-dependent MDS patients.
Blood Cancers Today Staff WritersMeeting News | December 16, 2022
MDS patients with del5q and one additional non-del20q cytogenetic abnormality are at higher risk.
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