The largest study yet comparing chimeric antigen receptor (CAR) T-cell therapy with the previous standard of care (SOC)... The CAR T-cell therapy received accelerated approval for adults with R/R FL after two or more lines of systemic therapy. Axicabtagene ciloleucel is the most cost-effective chimeric antigen receptor (CAR) T-cell therapy for patients with relapsed ... The overall efficacy of tisagenlecleucel was similar between the two groups. Flu/Cy led to more profound lymphocytopenia ... The European Commission has approved the chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel for the treatment of ... The U.S. Food and Drug Administration (FDA) has granted tisagenlecleucel accelerated approval for adult patients with ... The CAR T-cell therapy was approved for adult follicular lymphoma patients who have received two or more lines of systemic ... Two adults who received infusions of anti-CD19 CAR T-cell therapy tisagenlecleucel were in remission at nine and ten years. Tisagenlecleucel was well-tolerated with manageable toxicity in patients with primary central nervous system lymphoma.