Aaron Logan, MD, PhD, and Elias Jabbour, MD, discussed whether MRD negativity indicates a cure in patients with AML. Clinicians who specialize in BPDCN discuss the disease and novel therapeutic approaches to treating patients with BPCDN. Researchers retrospectively analyzed 580 patients with AML receiving HSCT between January 1999 and November 2020. Findings support the use of MRD negativity as a prognostic tool to measure deep response, leading to improved PFS. Ibrutinib and venetoclax demonstrated superior MRD responses in older/unfit patients with previously untreated CLL.