The proof-of-concept study showed that noninvasive hemoglobin measurement is “feasible,” but there were several ... One aim is to evaluate the efficacy of oral decitabine/cedazuridine and magrolimab in intermediate to HR MDS. Joseph Khoury, MD; Sanam Loghavi, MD; and Chadi Nabhan, MD, MBA, FACP, discuss the MDS classification systems. Dr. Garcia-Manero discusses key data from the phase III COMMANDS trial. Dr. Komrokji speaks about what might follow the recent FDA approval of luspatercept for certain patients with MDS. Researchers sought to differentiate the mechanism of action of luspatercept from epoetin alfa. Dr. Hasserjian discusses a presentation about the classification system that he gave at the SOHO Annual Meeting. A research team sought in their study to determine if the IPSS-M could also apply to CMML. "There's been a lot of focus on classifications and mutations: they're coming with a lot of force," Dr. Scheinberg said. Dr. Platzbecker joins Chadi Nabhan, MD, MBA, FACP, to discuss MDS at the Eleventh Annual Meeting of SOHO. Guillermo Garcia-Manero, MD, joins Chadi Nabhan, MD, MBA, FACP, to discuss the COMMANDS trial at the SOHO Annual Meeting. Allogeneic HSCT can yield favorable outcomes in treating patients with therapy-related MDS. A presentation by Dr. Rami Komrokji at the Eleventh SOHO Annual Meeting gave additional insights into the COMMANDS trial. Luspatercept is highly effective in treating ESA-naïve patients with LR-MDS. Response rates were high, and OS was improved in patients receiving venetoclax, although not statistically significant.