At SOHO 2021, Bijal Shah, MD, MS, of Moffitt Cancer Center, discussed what to expect going forward. At SOHO 2021, Greg Nowakowski, MD, of Mayo Clinic Rochester, discusses what to expect. At SOHO 2021, Susan O'Brien, MD, and Hagop Kantarjian, MD, addressed trends in hematologic malignancies. REVEAL is the largest prospective and contemporary cohort of patients with PV in the United States. The OPTIC study evaluated a response-based dose-reduction strategy to optimize the benefit-risk of a TKI in CP-CML. In patients with previously treated CLL and SLL, pirtobrutinib was safe and associated with high rates of response. Farhad Ravandi, MD, and Jeffrey Lancet, MD, squared off on this clinical quandary.