EHA-EBMT Fifth European CAR T-Cell Meeting
The EHA-EBMT Fifth European CAR T-Cell Meeting was held February 9-11 in Rotterdam, Netherlands, and focused on the latest advances in CAR T-cell therapies.
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Brexucabtagene autoleucel led to “high rates of durable response” in adults with relapsed/refractory B-cell ALL.
The study's investigators identified a four-gene model that segregated patients with different survival probabilities.
The estimated 24-month nonrelapse mortality was significantly lower in the CAR-T cohort than in the allogeneic HSCT cohort.
The research shows an emerging target for the development of novel CAR T-cell immunotherapies.
The researchers reported “high rates of durable responses” in most patients who were in high-risk disease subgroups.
Idecabtagene vicleucel led to “deeper and more durable responses” than standard regimens in the KarMMa-3 trial.
The results showed pembrolizumab was well tolerated, with 23.5% of patients achieving a complete response.
All patients had a complete response after the first infusion, while 67% had a complete response after the second infusion.
