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Marginal Zone Lymphoma
The latest news, research, and perspectives in marginal zone lymphoma (MZL).
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Understanding and Combatting Burnout in Hematologist-Oncologists
Melissa Badamo
Acute Lymphoblastic Leukemia
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March 14, 2025
Melody Smith, MD, MS, shares data on burnout in hematologist oncologists, why it occurs, and how to prevent it.
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NHL Experts Explore: What Do New Data Say About How to Use CAR T Cells, Bispecific Antibodies, Novel Therapies?
Andrew Moreno
Aggressive B-Cell Lymphoma
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March 14, 2025
A panel moderated by Neil Love, MD, explored clinical data to assess these treatment approaches for the various types of NHL.
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FDA Accepts Resubmitted Odronextamab BLA for Relapsed or Refractory Follicular Lymphoma
Andrew Moreno
Follicular Lymphoma
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February 26, 2025
Clinical evaluations of this bispecific antibody as monotherapy or in polytherapy for B-cell non-Hodgkin lymphomas continue.
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MHLW of Japan: Epcoritamab Bispecific Antibody Attains Follicular Lymphoma Indication
Andrew Moreno
Follicular Lymphoma
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March 14, 2025
This new approval adds upon the agent's indications for relapsed or refractory DLBCL and other large B-cell lymphomas.
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FDA Approves Brentuximab Vedotin Plus Lenalidomide, Rituximab for LBCL
Andrew Moreno
Aggressive B-Cell Lymphoma
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March 14, 2025
Approved for adults ineligible for autologous transplant or CAR T-cell therapy following at least two systemic therapies.
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Phase II Data: Liso-Cel Overall, Complete Response Rates Favorable in Both MZL, Follicular Lymphoma
Andrew Moreno
Transplantation & Cellular Therapy
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February 12, 2025
In the TRANSCEND FL trial liso-cel has met primary and secondary endpoints for both MZL and FL with manageable safety.
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FDA Approves In-Vitro Assay to Identify B-Cell Lymphomas, Plasma Cell Neoplasms
Andrew Moreno
Aggressive B-Cell Lymphoma
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January 29, 2025
The single-slide test helps clinicians differentiate more than 60 subtypes of these diseases from normal immune response.
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FDA Issues Clinical Hold on Tabelecleucel Monotherapy, Anti-CD19 CAR T-Cell Therapy INDs
Andrew Moreno
Transplantation & Cellular Therapy
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January 23, 2025
The therapies are under development for EBV-positive PTLD, non-Hodgkin lymphoma, and systemic lupus erythematosus.
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FDA, HHS Work on Recommendations Regarding Inclusion of Tissue Biopsies in Clinical Trials
Andrew Moreno
Acute Lymphoblastic Leukemia
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January 10, 2025
Issues addressed include mandatory versus optional biopsy, informed consent, and safety in both adult and pediatric patients.
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Five Years In, Axi-Cel Proves Resilience as Relapsed and Refractory iNHL Treatment
Nichole Tucker
Follicular Lymphoma
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January 10, 2025
The 5-year follow-up analysis of ZUMA-5 showed continued efficacy and no new safety signals.
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Dr. Xu Ji Highlights the Importance of Medicaid Coverage for Pediatric Lymphoma Care
Xu Ji, PhD, MSPH
Video Insights
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January 3, 2025
A database study has identified an association between disease stage at lymphoma diagnosis and time of Medicaid enrollment.
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IGHV1-2*04 Heavy Chain Dominance Drives Autoreactivity in SMZL
Julie Gould
Marginal Zone Lymphoma
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December 12, 2024
The functional and structural relevance of IGHV1-204 remains unclear for patients with splenic marginal zone lymphoma.
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WZTL-002 CAR T Cells Show Potential in Treatment of Relapsed or Refractory B-Cell NHL
Nichole Tucker
Follicular Lymphoma
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December 12, 2024
Results from the phase 1 ENABLE-1 study show complete responses comparable to commercial CAR Ts in B-cell NHL.
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Standard Of Care CD19 CAR T-Cell Therapy in Transformed Indolent Lymphoma Evaluated
Andrew Moreno
Meeting News
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December 9, 2024
A large, multicenter retrospective study found favorable efficacy and toxicity with this approach.
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BTK Degrader BGB-16673 Shows Durable Efficacy in Relapsed or Refractory (R/R) Indolent NHL
Julie Gould
Meeting News
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December 6, 2024
A phase I/II first-in-human study evaluates a new bivalent small molecule in relapsed or refractory FL and MZL.
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Favorable Long-Term Data Reported for Axi-cel
Patrick Daly
Marginal Zone Lymphoma
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November 14, 2023
Axi-cel showed promising efficacy and safety in patients with relapsed or refractory indolent non-Hodgkin lymphomas.
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Two Novel Surrogate Markers for Treatment Effect Validated in Extranodal MZL
Patrick Daly
Marginal Zone Lymphoma
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November 14, 2023
Two surrogate markers predicted treatment effect on eight-year progression-free survival in patients with extranodal MZL.
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Dr. Nastoupil on Lymphoma Highlights from the SOHO Annual Meeting
Loretta Nastoupil, MD
Meeting News
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December 10, 2024
Dr. Nastoupil spoke about how the meeting can help clinicians learn how apply knowledge from the latest research.
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Loretta Nastoupil, MD, on the Importance of Lymphoma Awareness
Loretta Nastoupil, MD
Hodgkin Lymphoma
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December 10, 2024
September is Leukemia and Lymphoma Awareness Month, with Lymphoma Awareness Day marked on September 15.
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Data on T-cell Exhaustion Support Earlier Use of T-cell-based Therapies in Splenic MZL
Leah Lawrence
Meeting News
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September 10, 2023
The composition of T cells in patients with sMZL may affect the efficacy of T-cell-based therapies.
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